Insulin resistance - Wikipedia, the free encyclopedia Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal actions of the hormone insulin. The body produces insulin, but the cells in the body become resistant to insulin and are unable to use it as effectively, lea
Mechanisms linking obesity to insulin resistance and type 2 diabetes. 1. Nature. 2006 Dec 14;444(7121):840-6. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Kahn SE, Hull RL, Utzschneider KM. Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese ..
Mechanisms linking obesity to insulin resistance and type 2 diabetes : Abstract : Nature Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other fact
Mechanisms of obesity-associated insulin resistance: many choices on the menu Inflammatory mechanisms Systemic chronic inflammation has been proposed to have an important role in the pathogenesis of obesity-related insulin resistance (Hotamisligil et al. 1995; Weisberg et al. 2003; Xu et al. 2003; Wellen and Hotamisligil 2005).
Molecular Mechanisms of Insulin Resistance, Obesity and Metabolic Syndrome | Biochemia Medica Insulin resistance is a state of impaired responsiveness to insulin action. The most common underlying cause is central obesity although primary insulin resistance in normal-weight individuals is also possible. Excess abdo-minal adipose tissue has been sh
Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role o Adipose Tissue, Obesity-Induced Inflammation, and Insulin Resistance There are two distinct forms of AT, brown adipose tissue (BAT) and white adipose tissue (WAT). BAT is typically associated with thermogenesis, although initially thought to disappear soo
Lipids in Health and Disease | Full text | Mechanisms underlying skeletal muscle insulin resistance Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking insulin resistance to these syndromes are not precisely defined yet, evidenc
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes : Abstract : Nature Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fa
Mechanisms for Insulin Resistance: Common Threads and Missing Links Here, we review several mechanisms proposed to explain the pathogenesis of insulin resistance—mainly, the development of insulin resistance from ectopic lipid accumulation, the development of “endoplasmic reticulum stress” and activation of the unfolded p
EQUINE OBESITY AND ITS ROLE IN INSULIN RESISTANCE, INFLAMMATION AND RISK FOR LAMINITIS EQUINE OBESITY AND ITS ROLE IN INSULIN RESISTANCE, INFLAMMATION AND RISK FOR LAMINITIS Rebecca A. Carter Dissertation submitted to the faculty of Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the ...
