Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes : Abstract : Nature Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fa
Adipocyte - Wikipedia, the free encyclopedia Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), which are also
Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance Screen reader users, click here to load entire articleThis page uses JavaScript to progressively load the article content as a user scrolls. Screen reader users, click the load entire article button to bypass dynamically loaded article content. ScienceDir
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue Despite being extensively studied, the pathogenesis of insulin resistance in obesity is still not completely understood. High levels of FFAs, as seen in obesity, reduce insulin-mediated glucose uptake by the GLUT4 transporter and inhibit the ...
Whole Health Source: Insulin and Obesity: Another Nail in the Coffin There are several versions of the insulin hypothesis of obesity, but the versions that are most visible to the public generally state that elevated circulating insulin (whether acute or chronic) increases body fatness. Some versions invoke insulin's effec
Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity : Nature The expression of insulin signal-related genes from the skeletal muscle of 10 weeks aged WT (white bar), TBP-2−/− (dark grey bar), ob/ob (black bar) and ob/ob·TBP-2−/− (light grey bar) mice. (a) Real-time PCR analyses were performed. Asterisk indicates *
The gut microbiota, obesity and insulin resistance The gut microbiota, obesity and insulin resistance Jian Shen a, Martin S. Obin c, Liping Zhao a, b, , a Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China b School of Life Sciences and ...
The usefulness of circulating adipokine levels for the assessment of obesity-related health problems In 1993, it was discovered that TNFα expression was up-regulated in WAT of obese mice [12]. The role of WAT as a hormone-producing organ became well recognized in 1994 with the discovery of leptin as an adipocyte-secreted protein [13]. Systemic analysis o
The Inflammatory Syndrome: The Role of Adipose Tissue Cytokines in Metabolic Disorders Linked to Obe The existing paradigm of adipose tissue endocrinology has been changed significantly by introducing immune cells as a source of inflammatory mediators released from adipose tissue, as well as a paracrine regulator of adipocyte function and ...
Whole Health Source: Fat Tissue Insulin Sensitivity and Obesity Strontium Pup said... “The idea that insulin acts on fat cells to promote obesity requires that insulin suppress fat release in people with more fat (or people who are gaining fat) to a greater extent than in lean people.” I just don’t think this can be r
